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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MSH6 All Species: 19.09
Human Site: S280 Identified Species: 30
UniProt: P52701 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52701 NP_000170.1 1360 152786 S280 G S S D E I S S G V G D S E S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001113749 1360 152750 S280 G S S D E I S S G V G D S E S
Dog Lupus familis XP_531814 1283 145094 S263 K S A L N A Y S A P Q N S E S
Cat Felis silvestris
Mouse Mus musculus P54276 1358 151058 S280 G S S D D A S S G V G D S D S
Rat Rattus norvegicus XP_002726765 1361 151628 S283 G S S D E V S S G V G D S D S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419359 1466 164165 G384 S S E E A S S G V D E N E A T
Frog Xenopus laevis NP_001089247 1340 149481 G263 S S G V D E A G L S E P D S E
Zebra Danio Brachydanio rerio NP_878280 1369 153213 S282 E E E E G V N S G A E E E E S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VUM0 1190 133117 A185 T I Q L A E G A T F Q E K L K
Honey Bee Apis mellifera XP_392346 1120 127429 V115 E S E E S D S V S E G V S E S
Nematode Worm Caenorhab. elegans NP_491163 1186 133609 D181 D K M D K I M D G E G E R K R
Sea Urchin Strong. purpuratus XP_797647 1335 149141 A262 L D E D E I S A S E T E S D P
Poplar Tree Populus trichocarpa XP_002320307 1288 142120 V270 A S T G G V R V S V V E P V K
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04716 1324 146779 T263 V E E K D E E T S K V N R V S
Baker's Yeast Sacchar. cerevisiae Q03834 1242 140062 D237 F T R N I S R D N S K K K S R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98.3 88.1 N.A. 85.8 86.4 N.A. N.A. 64.2 66.5 60 N.A. 39 41.2 34.4 48.6
Protein Similarity: 100 N.A. 98.6 91.3 N.A. 92.1 92.8 N.A. N.A. 75.4 79.9 74.9 N.A. 57.6 58 52.7 66.6
P-Site Identity: 100 N.A. 100 33.3 N.A. 80 86.6 N.A. N.A. 13.3 6.6 26.6 N.A. 0 40 26.6 33.3
P-Site Similarity: 100 N.A. 100 46.6 N.A. 93.3 100 N.A. N.A. 33.3 20 53.3 N.A. 13.3 46.6 46.6 53.3
Percent
Protein Identity: 36.1 N.A. N.A. 33.2 29 N.A.
Protein Similarity: 52 N.A. N.A. 51.4 49.1 N.A.
P-Site Identity: 13.3 N.A. N.A. 6.6 0 N.A.
P-Site Similarity: 33.3 N.A. N.A. 26.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 7 0 14 14 7 14 7 7 0 0 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 7 0 40 20 7 0 14 0 7 0 27 7 20 0 % D
% Glu: 14 14 34 20 27 20 7 0 0 20 20 34 14 34 7 % E
% Phe: 7 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % F
% Gly: 27 0 7 7 14 0 7 14 40 0 40 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 0 7 27 0 0 0 0 0 0 0 0 0 % I
% Lys: 7 7 0 7 7 0 0 0 0 7 7 7 14 7 14 % K
% Leu: 7 0 0 14 0 0 0 0 7 0 0 0 0 7 0 % L
% Met: 0 0 7 0 0 0 7 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 7 7 0 7 0 7 0 0 20 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 7 0 7 7 0 7 % P
% Gln: 0 0 7 0 0 0 0 0 0 0 14 0 0 0 0 % Q
% Arg: 0 0 7 0 0 0 14 0 0 0 0 0 14 0 14 % R
% Ser: 14 60 27 0 7 14 47 40 27 14 0 0 47 14 54 % S
% Thr: 7 7 7 0 0 0 0 7 7 0 7 0 0 0 7 % T
% Val: 7 0 0 7 0 20 0 14 7 34 14 7 0 14 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _